The Impact of Molecular Features on Outcome in Black Women With Type 1 Endometrial Cancer
Among women with endometrial cancer (EC), African American or Black (AAoB) population share a disproportionate burden of cancer deaths. Previous research exploring genetic and molecular explanations revealed White (W) women with EC are more likely to have mutations in PTEN, while AAoB women have higher rates of mutations in p53. However, these studies did not stratify EC by subtype, which occur at different rates among racial groups.
Here, we aim to focus on molecular differences between racial groups, specifically in Type 1 EC (T1EC). Based on 5 years of data, overall survival (OS) rates among W women with T1EC are better than AAoB. PTEN mutation confers a survival advantage in W but not in AAoB, indicating that in AAoB, PTEN may play a different role or other factors may override the PTEN advantage. A better understanding of the downstream signaling pathways of common mutations in T1EC, as well as understanding the effect of other factors including SES and access to healthcare, is necessary to further elucidate factors that contribute to racial disparities in T1EC.
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Link to the abstract:
This figure depicts the top 10 most significantly altered genes between the W and AAoB subgroups.
This abstract was originally presented at the ASCO Annual Meeting 2022.
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