End-to-End Risk Stratification Model to Predict Progression from Barrett’s Esophagus to Esophageal Adenocarcinoma
Authors: Daniel Franklin, Tara Pattilachan, F Scott Corbett, Anthony Magliocco, Domenico Coppola
Journal: Laboratory Investigation | Volume 102
Publisher: Springer Nature
Esophageal adenocarcinoma (EAC) surfaces from a dysplastic progression of Barrett's esophagus (BE), with 8% of patients with BE developing EAC; however, there is no current model that directly predicts the risk of progression from image tiles from biopsy slides. Herein, we designed an end-to-end model stratification model to predict BE progression to EAC without the need to triage patient data and instead, directly predict progression from whole slide images. Non-progressors (BEN) did not develop dysplasia or carcinoma upon follow-up of > 7 years, progressors (BEP) developed carcinoma upon follow-up of 3-4 years.