Key Genetic Characteristics of Pediatric AML Between Black/African Americans and Caucasians
Authors: Roy Khalife, So Hyeon Park, Anthony Magliocco
Journal: Pediatric Blood & Cancer
Conference: ASPHO Conference
Publisher: WILEY
Acute Myeloid Leukemia (AML) constitutes 15-20% of all pediatric acute leukemias, with an average survival rate of 70%. However, the black/African American subgroup do significantly worse than whites with AML. Molecular differences such as gene alterations, mRNA expression and methylation were analyzed for pediatric AML cases. Several molecular differences were observed, such as the upregulated olfactory gene alterations in black/African Americans; olfactory genes have been known to be overexpressed in a variety of cancers, and researchers are showing interest in its potential for targeted therapy.